Overcoming resistance to immunotherapy using radiation

Data are emerging that radiotherapy may help overcome resistance to PDL-1 immunotherapy and restore its ability to kill cancer cells. Xiaohong Wang and colleagues in James Welsh’s lab have now published in Cancer Research one way that this is actually working. Using a mouse model of non small-cell lung cancer, these researchers demonstrate how cells sensitive to immunotherapy and those that are resistant differ. Further, they also show how radiation given to the resistant tumors can alter the immune response and re-establish cell death by changing the expression of the MHC Class I protein. Read more about this in the February issue of Cancer Research.

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